Zhang et al 2023 – Vasa praevia

Goldstone et al-In adults with standard-risk Rowe et al-Induction therapy for adults Shaikh et al-Outcome of adult patients Sive et al-Outcomes in older adults with acute lymphoblastic leukaemia Marks et al-The clinical characteristics

Sive et al-Outcomes in older adults with acute lymphoblastic leukaemia

Shaikh et al-Outcome of adult patients

Rowe et al-Induction therapy for adults

Using Smartwatches to Observe Changes in Activity During Recovery

A Retrospective Analysis of the Performance of intensive care unit severity scoring systems across different ethnicities

Implementation of the ABCDEF Bundle for Critically Ill ICU Patients During the COVID-19 Pandemic: A Multi-National 1-Day Point Prevalence Study

Performance of Calibration of Performance Model Scores in a Large Single Centre Database

Performance of intensive care unit severity scoring systems across different ethnicities in the USA: a retrospective observational study

Nutrition therapy in the intensive care unit during the COVID-19 pandemic: Findings from the ISIIC point prevalence study

Position statement on visiting in adult critical care units in the UK

Patients’ and relatives’ experiences of transfer from intensive care unit to wards

NCEPOD Tracheostomy Care Study

33rd International Symposium on Intensive Care and Emergency Medicine

Tranexamic acid in traumatic bleeding — for everyone?

Acute Myeloid Leukemia: Low Peripheral Blast Count May Predict Better Outcome with Best Supportive Care than with Intensive Chemotherapy in Older Patients

879P – Germline sequencing of advanced prostate cancer patients in the BARCODE2 trial

Development of core outcome sets for effectiveness trials of interventions to prevent and/or treat delirium (Del-COrS): study protocol

Effectiveness of an active continuous surveillance program for Intensive Care Units infections based on the EPIC III (Extended Prevalence of Infection in Intensive Care) approach

PATCH – Prostate adenocarcinoma: transcutaneous hormones. A randomised comparison evaluating cardiovascular morbidity and mortality of transdermal oestradiol versus luteinising hormone-releasing hormone agonists in advanced prostate cancer

SCOT: Short Course Oncology Therapy – a comparison of 12 and 24 weeks of adjuvant chemotherapy in colorectal cancer

Evaluating the efficacy of thoracoscopy and talc poudrage versus pleurodesis using talc slurry (TAPPS trial): protocol of an open-label randomised controlled trial

Effect of opioids vs NSAIDs and larger vs smaller chest tube size on pain control and pleurodesis efficacy among patients with malignant pleural effusion: the TIME1 randomized clinical trial

Cheang, M et al: Concordance of intrinsic subtyping and risk of recurrence (ROR) scores between matched primary and metastatic tissue from Negative Breast Cancer Trial (TNT)Triple

NeoCLEAR Results Article ARCTIC Results Article

ARCTIC Results Article

 

 

The SHIELD Study

Proctor et al-An international approach Boll+Gorgen-The treatment of older Hodgkin lymphoma patients Proctor et al-Evaluation of treatment outcome

Boll+Gorgen-The treatment of older Hodgkin lymphoma patients

Proctor et al-Evaluation of treatment outcome

Myeloma X Relapse

Goldstone et al-In adults with standard-risk Rowe et al-Induction therapy for adults Shaikh et al-Outcome of adult patients Sive et al-Outcomes in older adults with acute lymphoblastic leukaemia Marks et al-The clinical characteristics Cook et al-The effect of salvage autologous Morris et al – Patient perceptions of second transplants Cook – The impact of cytogenetics Cook et al-High-dose chemotherapy Ahmedzai et al-Patient-reported outcome results

Snowden et al-Association of genetic variants

Ahmedzai et al-Patient-reported outcome results

Cook et al-High-dose chemotherapy

Cook – The impact of cytogenetics

Morris et al – Patient perceptions of second transplants

NICE FIT

Using the faecal immunochemical test in patients with rectal bleeding: evidence from the NICE FIT study

Faecal immunochemical testing in symptomatic patients to prioritize investigation: diagnostic accuracy from NICE FIT Study

Faecal immunochemical test is superior to symptoms in predicting pathology in patients with suspected colorectal cancer symptoms referred on a 2WW pathway: a diagnostic accuracy study

PROTECT-ASUC

Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study

PROTECT-ASUC: COVID-19 pandemic response of assessment, endoscopy and treatment in acute severe ulcerative colitis. A multi-centre observational case-control study

 

ETHICUS II

Variations in end-of-life practices in intensive care units worldwide (Ethicus-2): a prospective observational study

Communication and decision processes in End of Life Decision in German intensive care units – results from the ETHICUS-2 study

End-of-life practices in 11 German intensive care units: results from the ETHICUS-2 study

End-of-life practices in 11 German intensive care units: results from the ETHICUS-2 study

NEOMERO-2

 Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies

Final report summary – NEOMERO (European multiccenter network to evaluate pharmacokinetics, safety and efficacy of meropenem in neonatal sepsis and meningitis)

COMICE 99/27/05

Comparative effectiveness of MRI in breast cancer (COMICE) trial: a randomised controlled trial

The UK NIHR multicentre randomised COMICE trial of MRI planning for breast conserving treatment for breast cancer

Magnetic resonance imaging in breast cancer: results of the COMICE trial

MR imaging in breast cancer – results of the COMICE trial

Multicentre randomised controlled trial examining the cost-effectiveness of contrast-enhanced high field magnetic resonance imaging in women with primary breast cancer scheduled for wide local excision (COMICE)

MANTA

Fulvestrant plus Vistusertib vs Fulvestrant plus Everolimus vs Fulvestrant alone for women with hormone receptor-positive metastatic breast cancer: the MANTA Phase 2 randomized clinical trial

AML-15

Optimization of chemotherapy for younger patients with acute myeloid leukemia: results of the Medical Research Council AML15 Trial

The addition of Gemtuzumab Ozogamicin to induction chemotherapy for AML improves disease free survival without extra toxicity: preliminary analysis of 1115 patients in the MRC AML15 Trial

Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: results of the United Kingdom MRC AML-15 trial

Predictive value of minimal residual disease (MRD) monitoring by RQ-PCR in WT1 positive patients entered in the UK MRC AML-15 trial

Patterns of recruitment into acute myeloid leukaemia (AML) 15 and outcome for young patients with AML at a single referral centre

CROMIS-2

The Clinical Relevance of Microbleeds in Stroke study (CROMIS-2): rationale, design, and methods

Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study

Baseline factors associated with early and late death in intracerebral haemorrhage survivors

Oral anticoagulants in the oldest old with recent stroke and atrial fibrillation

CALORIES

A multicentre, randomised controlled trial comparing the clinical effectiveness and cost-effectiveness of early nutritional support via the parenteral versus the enteral route in critically ill patients (CALORIES)

Trial of the route of early nutritional support in critically ill adults

Effectiveness and cost-effectiveness of early nutritional support via the parenteral versus the enteral route for critically ill patients

The CALORIES trial: statistical analysis plan

EMMACE-3

Evaluation of the methods and management of acute coronary events (EMMACE)-3: protocol for a longitudinal study

LOPAS II

Factors influencing work disability in psoriatic arthritis: first results from a large UK multicentre study

Work disability after initiation of anti-TNF and DMARD treatment in psoriatic arthritis; investigator LED, UK, Multicentre Observational Cohort Study (LOPAS II)

Joint count reliability in psoriatic arthritis observational trials – an unreported problem

Effect of anti-TNF and conventional synthetic disease-modifying and anti-rheumatic drug treatment on work disability and clinical outcome in a multicentre observational cohort study of psoriatic arthritis

CSAW

The CSAW study (Can Shoulder Arthroscopy Work?) – a placebo-controlled surgical intervention trial assessing the clinical and cost effectiveness of arthroscopic subacromial decompression for shoulder pain: study protocol for a randomised controlled trial

Arthroscopic subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial

ASPRE

Study protocol for the randomised controlled trial: combined multimarker screening and randomised patient treatment with Aspirin for evidence-based PREeclampsia prevention (ASPRE)

ASPRE trial: performance of screening for preterm pre-eclampsia

ASPRE trial: incidence of preterm pre-eclampsia in patients fulfilling ACOD and NICE criteria according to risk by FMF algorithm

Reasons for accepting or declining participation in the ASPRE trial: a qualitative study with women at high risk of preterm pre-eclampsia

EnROL

EnROL: a multicentre randomised trial of conventional versus laparoscopic surgery for colorectal cancer within an enhanced recovery programme

RADI-CRT

A multicentre prospective randomized controlled trial of cardiac resynchronization therapy guided by invasive dP/dt

ECLIPSE

Exploring the current landscape of intravenous  infusion practices and errors (ECLIPSE): protocol for a mixed-methods observational study

HIPvac Trial

Human papillomavirus infection: protocol for a randomised controlled trial of imiquimod cream (5%) versus podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in the treatment and prevention of recurrence of anogenital warts (HIPvac trial)

FRAGMATIC

FRAGMATIC: a randomised phase III clinical trial investigating the effect of fragmin added to standard therapy in patients with lung cancer

Randomized Phase III trial of standard therapy plus low molecular weight heparin in patients with lung cancer: FRAGMATIC trial

Further results of the FRAGMATIC trial of thromboprophylaxis in lung cancer

EPOCH

Cost-effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery: learning from 15, 856 patients

The Enhanced Peri-Operative Care for High-riak patients trial: an independent discussion and commentary

Learning from the EPOCH trial (Editorial). What we have learnt from a trial of an intervention to improve survival following emergency laparotomy

A commentary on: “Cost-effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery” (Int J Surg 2019; 70: 35-43)

ISOS

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries

Postoperative infectious complications in elderly patients after elective surgery in China: results of a 7-day cohort study from the International Surgical Outcomes Study

Postoperative infection and mortality following elective surgery in the International Surgical Outcomes Study (ISOS)

International Surgical Outcomes Study (ISOS) sub-study: post-operative infection (Statistical Analysis Plan)

TICH2

Predictors and outcomes of neurological deterioration in intracerebral haemorrhage: results from the TICH-2 randomized controlled trial

Transexamic acid for hyperacute primary intracerebral haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial

Outcomes in antiplatelet-associated intracerebral haemorrhage in the TICH-2 randomized controlled trial

Brief consent methods enable rapid enrolment in acute stroke trial: results from the TICH-2 randomized controlled trial

Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT

SPREE

Comparison of diagnostic accuracy of early screening for pre-eclampsia by NICE guidelines and a method combining maternal factors and biomarkers: results of SPREE

Mini-combined test with NICE guidelines for early risk-assessment for pre-eclampsia: the SPREE diagnostic accuracy study

Protocol for the prospective validation study: ‘Screening programme for pre-eclampsia’ (SPREE)

 

TICH-2 MRI sub study

Effect of tranexamic acid administration on remote cerebral ischemic lesions in acute spontaneous intracerebral haemorrhage: a substudy of a randomized clinical trial

Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary intracerebral haemorrhage’ (TICH-2) trial

Rationale and design of tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2) MRI substudy

Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial

Results from the tranexamic acid for primary intracerebral haemorrhage-2 (TICH-2) trial

UKCLL 01FCM/FCM-R

A randomized phase II trial of fludarabine, cyclophosphamide and mitoxantrone (FCM) with or without rituximab in previously treated chronic lymphocytic leukaemia

PiPs

Bifidobacterium breve BBG-001 in very preterm infants: a randomised controlled phase 3 trial

Probiotics in very preterm infants: the PiPs trial

https://adc.bmj.com/content/99/suppl_2/a23.3.abstract?casa_token=BPlpvpvjzuoAAAAA:tdSDhScsi34ilhXf11z4tqACMkwGvVCtlyz2Psd_vJ7rpfvUiGg4K2t9Cgtl2wP8VKhKdVMIfKUG

The microbiome of infants recruited to a randomised placebo-controlled probiotic trial (PiPs trial)

IELSG-19

Final results of the IELSG-19 randomized trial of mucosa-associated lymphoid tissue lymphoma: improved event-free and progression-free survival with Rituximab plus chlorambucil versus either chlorambucil or rituximab monotherapy

ZICE

Zoledronate versus ibandronate comparative evaluation (ZICE) trial – first results of a UK NCRI 1,405 patient phase III trial comparing oral ibandronate versus intravenous zoledronate in the treatment of breast cancer patients with bone metastases

Interim safety data on the ZICE trial: a randomized phase III, open-label, multicentre, parallel group clinical trial to evaluate and compare the efficacy, safety profile, and tolerability of oral ibandronate versus intravenous zoledronate in the treatment of patients with breast cancer with bone metastases

EPIC (NCRN448)

Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial

Epic: a phase 3 trial of Ponatinib compared with imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CP-CML)

EPIC: a phase III trial of ponatinib (PON) versus imatinib (IM) in patients (pts) with newly diagnosed CP-CML

EPIC: a phase III randomized, open-label study of ponatinib versus imatinib in adult patients with newly diagnosed chronic myeloid leukemia in chronic phase

EPIC: a phase 3 trial of Ponatinib compared with Imatinib in CP-CML patients

LeoPARDS

Levosimendan for the prevention of acute organ dysfunction in sepsis

An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial

Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis

CEDAR

A phase II, randomised, open-label study of gemcitabine/carboplatin first-line chemotherapy in combination with or without the antisense oligonucleotide apatorsen (OGX-427) in advanced squamous cell lung cancers

FREE

Family-reported experiences evaluation (FREE) study: a mixed-methods study to evaluate families’ satisfaction with adult critical care services in the NHS

Family satisfaction with critical care in the United Kingdom

Psychometric assessment of the Family Satisfaction in the Intensive Care Unite questionnaire in the United Kingdom

Phase 1 of the Family-Reported Experiences Evaluation Study

Psychometric assessment of the family satisfaction in the intensive care unit (fc-icu-24) questionnaire among family members of patients admitted to adult general icus in the united kingdom

FH01-HTA Mammography Trial

Mammographic surveillance in women younger than 50 years who have a family history of breast cancer: tumour characteristics and projected effect on mortality in the prospective, single-arm, FH01 study

Elementary flaws in the FH01 study

Evaluation of mammographic surveillance services in women aged 40-49 years with a moderate family history of breast cancer: a single-arm cohort study

EUROBACT II

Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study

https://link.springer.com/article/10.1007/s00134-022-06944-2

Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study

https://ccforum.biomedcentral.com/articles/10.1186/s13054-022-04166-y

DALES

DALES, Drug Allergy Labels in Elective Surgical patients: a prospective multicentre cross-sectional study of incidence, risks, and attitudes in penicillin de-labelling strategies

DALES, Drug Allergy Labels in Elective Surgical patients: a prospective, multicentre cross-sectional study of prevalence, nature and anaesthetists’ approach to management

MRC Myeloma IX

The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis

First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC myeloma IX): a randomised controlled trial

A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: analysis of patients treated in the MRC Myeloma IX trial

Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised trial

Long-term follow-up of MRC Myeloma IX trial: survival outcomes with bisphosphonate and thalidomide treatment

Cyclophosphamide, thalidomide, and dexamethasone as induction therapy for newly diagnosed multiple myeloma patients destined for autologous stem-cell transplantation: MRC Myeloma IX randomized trial results

Thalidomide maintenance significantly improves progression-free survival (PFS) and overall survival (OS) of myeloma patients when effective relapse treatments are used: MRC Myeloma IX results

The Medical Research Council Myeloma IX trial: the impact on treatment paradigms

Quality of life during and following sequential treatment of previously untreated patients with multiple myeloma: findings of the Medical Research Council Myeloma IX randomised study

Maintenance thalidomide may improve progression free but not overall survival; results from the Myeloma IX maintenance randomisation

Further analyses of the Myeloma IX study

MRC Myeloma IX, 6 year median follow-up (FU) highlights the importance of long-term FU in myeloma clinical trials and differential effects of thalidomide in high- and low-risk disease

Minimal residual disease assessed by multiparameter flow cytometry in multiple myeloma: impact on outcome in the Medical Research Council Myeloma IX study

The Medical Research Council Myeloma IX Trial: new clinical insights on the anticancer effects of zoledronic acid in patients with multiple myeloma

Thalidomide combinations improve response rates; results of the MRC IX study

PRoVENT

Rationale and study design of Provent – an international multicenter observational study on practice of ventilation in critically ill patients without ARDS

Potentially modifiable respiratory variables contributing to outcome in ICU patients without ARDS: a secondary analysis of PRoVENT

Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study

POPPI

A nurse-led, preventive, psychological intervention to reduce PTSD symptom severity in critically ill patients: the POPPI feasibility study and cluster RCT

Effect of a nurse-led preventive psychological intervention on symptoms of posttraumatic stress disorder among critically ill patients: a randomized clinical trial

Psychological Outcomes following a nurse-led Preventative Psychological Intervention for critically ill patients (POPPI): protocol for a cluster-randomised clinical trial of a complex intervention

Psychological Outcomes following a nurse-led Preventive Psychological Intervention (POPPI) trial

 

 

SMILE

Self-management education for adults with poorly controlled epilepsy (SMILE (UK)): a randomised controlled trial protocol

Self-management education for adults with poorly controlled epilepsy (SMILE (UK)): statistical, economic and qualitative analysis plan for a randomised controlled trial

The effectiveness of a group self-management education course for adults with poorly controlled epilepsy, SMILE (UK): a randomized controlled trial

Self-management for people with poorly controlled epilepsy: participants’ views of the Self-Management in epILEpsy (SMILE) program

RAIN

Risk adjustment in neurocritical care (RAIN) – prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study

External validation and recalibration of risk prediction models for acute traumatic brain injury among critically ill adult patients in the United Kingdom

Prospective external validation of risk prediction models for acute traumatic brain injury in UK critical care units: the Rain study

PROMPTS

Observation versus screening spinal MRI and pre-emptive treatment for spinal cord compression in patients with castration-resistant prostate cancer and spinal metastases in the UK (PROMPTS): an open-label, randomised, controlled, phase 3 trial

Pre-emptive or reactive? PROMPT spinal screening in metastatic castration-resistant prostate cancer

FIRE

Development and validation of a risk model for identification of non-neutropenic, critically ill adult patients at high risk of invasive Candida infection: the Fungal Infection Risk Evaluation (FIRE) study

Invasive fungal infections in patients with cirrhosis – subanalysis of the fungal infection risk evaluation (FIRE) study

An integrated approach to evaluating alternative risk prediction strategies: a case study comparing alternative approaches for preventing invasive fungal disease

SAKK 08/11

Orteronel switch maintenance therapy in metastatic castration resistant prostate cancer after first-line docetaxel: a multicentre, randomized, double-blind, placebo-controlled trial (SAKK 08/11)

Orteronel (Ort) maintenance therapy in patients (pts) with metastatic castration resistant prostate cancer (mCRPC) and non-progressive disease after first-line docetaxel (Doc) therapy: results of a multicentre randomized double-blind placebo-controlled phase III trial (SAKK 08/11)

NEON

Nutritional Evaluation and Optimisation in Neonates (NEON) trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised double-blind controlled trial

Nutritional Evaluation and Optimisation in Neonates: a randomized, double-blind controlled trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition

Standardising neonatal parenteral nutrition: a suggested approach

Nutritional Evaluation and Optimisation in Neonates trial: is the protein-to-energy ratio important?

EuSOS

EuSOS: European Surgical Outcomes Study

American Society of Anesthesiologists score: still useful after 60 years? Results of the EuSOS Study

Variation in haemodynamic monitoring for major surgery in European nations: secondary analysis of the EuSOS dataset

Swedish Surgical Outcome Study (SweSOS), a sub study of the European Surgical Outcomes Study (EuSOS). Characteristics and outcome of the Swedish subset of EuSOS to identify the predictors of short- and long-term mortality in Sweden. Analytical, descriptive and prospective cohort study

ProMISe

Protocolised management in sepsis (ProMISe): a multicentre randomised controlled trial of the clinical effectiveness and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock

Protein misfolding, amyotrophic leteral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial)

InCiTe

Intracranial haemorrhage in thrombocytopenic haematology patients = a nested case-controlled study: the InCiTe study protocol

TARDIS

Statistical analysis plan for the ‘triple antiplatelets for reducing dependency after ischaemic stroke’ (TARDIS) trial

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388)

Learning from TARDIS: time for more focused trials in stroke prevention

Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: the TARDIS RCT

Baseline characteristics of the 3096 patients recruited into the ‘Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke’ trial

65 Trial

Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: statistical and health economic analysis plan for the 65 trial

Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill people aged 65 and over: the 65 RCT

Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: protocol for the 65 randomised clinical trial

A machine-learning approach for estimating subgroup- and individual-level treatment effects: an illustration using the 65 Trial

OSCAR

A randomised controlled trial and cost-effectiveness analysis of high-frequency oscillatory ventilation against conventional artificial ventilation for adults with acute respiratory distress syndrome. The OSCAR (OSCillation in ARDS) study

Substantial and non-substantial amendments to the OSCAR Protocol

LRF CLL4

Mutational status of the TP53 Gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial

Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 trial): a randomised controlled trial

The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial

Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial

The morphology of CLL revisited: the clinical significance of prolymphocytes and correlations with prognostic/molecular markers in the LRF CLL4 trial

Patients’ experience of chronic lymphocytic leukaemia: baseline health-related quality of life results from the LRF CLL4 trial

Telomere length predicts progression and overall survival in chronic lymphocytic leukaemia: data from the UK LRF CLL4 trial

The association between deaths from infection and mutations of the BRAF, FBXW7, NRAS and XPO1 genes: a report from the LRF CLL4 trial

Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial: blockade at the level of p21 is associated with short response duration

The use of individualized tumor response testing in treatment selection: second randomization results from the LRF CLL4 trial and the predictive value of the test at trial entry

Early results from the LRF CLL4: a UK multicenter randomized trial

Evaluation of the serum markers in the LRF CLL4 trial: β2-microglobin but not serum free light chains, is an independent marker of overall survival

Response to therapy and survival in CLL is influenced by genetic markers. Preliminary analysis from the LRF CLL4 trial

A comparison of the efficacy and safety of oral and intravenous fludarabine in chronic lymphocytic leukemia in the LRF CLL4 trial

Prognostic factors in the UK LRF CLL4 trial

Comparison of oral and intravenous fludarabine in the LRF CLL4 trial

Quality of life in the LRF CLL4 trial

The lack of survival differences in randomised trials in CLL may be related to the effect of second line therapies. A report from the LRF CLL4 trial

The contribution of gene mutations to long-term clinical outcomes: data from the randomised UK LRF CLL4 trial

Drug sensitivity by TRAC (DiSC) assay as a prognostic factor for patient response in untreated CLL: results from the UK LRF CLL4 trial

HeadPoST version 2.1

Oxygen desaturation and adverse outcomes in acute stroke: secondary analysis of the HeadPoST study

Head Position in Stroke Trial (HeadPoST) – sitting up vs lying-flat positioning of patients with acute stroke: study protocol for a cluster randomised controlled trial

Blood pressure variability and outcome in acute ischemic and hemorrhagic stroke: a post hoc analysis of the HeadPoST study

Head position and cerebral blood flow in acute ischemic stroke patients: protocol for the pilot phase, cluster randomized, head position in acute ischemic stroke trial (HeadPoST pilot)

Prognostic significance of early urinary catheterization after acute stroke: secondary analyses of the international HeadPoST trial

Low blood pressure and adverse outcomes in acute stroke: HeadPoST study explanations

Statistical analysis plan for the Head Position in Stroke Trial (HeadPoST): an international cluster cross-over randomized trial

Quantifying regional variations in components of acute stroke unit (ASU) care in the international HeadPoST study

No benefit of flat head positioning in early moderate-severe acute ischaemic stroke: a HeadPoST study subgroup analysis

Influence of including patients with premorbid disability in a acute stroke trials: the HeadPoST experience

Cluster-randomized, crossover trial of head positioning in acute stroke

BADBIR

The British Association of Dermatologists’ Biologic Interventions Register (BADBIR): design, methodology and objectives

Differential drug survival of biologic therapies for the treatment of psoriasis: a prospective observational cohort study from the British Association of Dermatologists’ Biologic Interventions Register (BADBIR)

DecubICUs

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Correction to above article

Maternal and neonatal complications in pregnancies with and without pre-gestational diabetes mellitus

Karkia et al 2023