U-LOOP Trial – UmbiLical cOrd abnOrmalities in the Prediction of adverse pregnancy outcomes

U-LOOP Study Poster

Patient information sheet – U-LOOP study – Version 1.2- 31st August 2023 – Localised

Patient consent form U-LOOP study – Version 1.2 – 25th July 2023 – Final – Localised

 

At Medway NHS Foundation Trust there are multiple ongoing research studies. We cover a wide range of different topics across the hospital. At Medway NHS Foundation Trust we regularly have more than 90 studies ongoing at any time.

Within the Hospital, we aim to cover as many specialist areas as possible from young to old, cancers to infections. Some of our most successful research areas include reproductive health and childbirth, cancer and critical care.

Available Patient Information Sheets for Ongoing Fetal Medicine Studies

Prevention of PE PIS Version 1.2 Date 29.03.23 (Localised)

Below are our open studies:

Ageing

Currently no open (recruiting) studies at Medway NHS Foundation Trust. Go to Be Part of Research to find studies at other sites

Anaesthetics, Perioperative & Pain Management

CAMELOT

Continuous rectus sheath Analgesia in eMErgency LaparOTomy. Multi-centre, randomised sham-controlled trial of rectus sheath catheter-delivered local anaesthetic infusion compared with the usual care in patients undergoing emergency bowel surgery.

Gastroenterology

IBD Bioresource

The UK Inflammatory Bowel Disease Bioresource: Progressing from Genetics to Function and Clinical Translation in Crohn’s Disease & Ulcerative Colitis

Genetics

Currently no open (recruiting) studies at Medway NHS Foundation Trust. Go to Be Part of Research to find studies at other sites.

Haematology (blood)

Beta-blockers or placebo for primary prophylaxis (BOPPP) Trial

Beta Blockers or placebo for primary prophylaxis of oesophageal varices (BOPPP Trial). A blinded, multi-centre, clinical effectiveness and cost-effectiveness randomised controlled trial

UK Childhood ITP Registry

The UK Paediatric ITP Registry

UKAITPR

United Kingdom Adult Idiopathic Thrombocytopenic Purpura (ITP) Registry: An Investigation of Disease Progression, Treatment Effectiveness, and Co-morbid Conditions.

 

 

 

 

Cancer

ICI Genetics

Identification of genetic factors that predispose to immune checkpoint inhibitor toxicity.

OPTIMA

Optimal Personalised Treatment of early breast cancer using Multiparameter Analysis

PARADIGM

Plasma analysis for response assessment and to direct the management of metastatic prostate cancer

SMR-3760

Phase II, open label, single arm study to investigate anti-tumor effect of ixabepilone in patients with locally recurrent or metastatic breast adenocarcinoma (mBC) selected by the ixabepilone DRP after failure of an anthracyclune and taxanes.

HoT

Hemithyroidectomy or Total-Thyroidectomy in ‘low-risk’ thyroid cancers

ALLTogether1

ALLTogether1– A Treatment study protocol of the ALLTogether Consortium for children and young adults (0-45 years of age) with newly diagnosed acute lymphoblastic leukaemia (ALL)

RAINBOW

Randomised phase II/III study of Rituximab and Ibrutinib (RI) versus Dexamethasone, Rituximab and Cyclophosphamide (DRC) as  initial therapy for Waldenstrom’s macroglobulinemia.

HER2-RADICAL

The HER2-RADiCAL study (Response ADaptive CAre pLan) – Tailoring treatment for HER2 positive early breast cancer

Health Services

No current open and recruiting studies. Go to https://bepartofresearch.nihr.ac.uk/ to find studies at other sites.

Hepatology (Liver)

NAFLD BioResource

The NAFLD BioResource, part of the NIHR BioResource – A Research Study to Characterise Novel Clinical and Genetic Phenotypes, and Understand the Natural History of Non-Alcoholic Fatty Liver Disease (NAFLD)

Infectious Diseases

RECOVERY

Randomised Evaluation of COVID-19 Therapy (RECOVERY)

 

Haematology

CADENCE Registry

Cold Agglutinin Disease Real World Evidence Registry

Cardiovascular (Heart) Disease

MPP VARR

The effect of MultiPoint pacing on reverse remodelling and the incidence of ventricular arrhythmias – The MPP VARR Study

PROTECT-HF

Physiological vs Right ventricular pacingOutcome Trial Evaluated for bradyCardia Treatment

Atrial Fibrillation After Resection (AFAR)

Atrial Fibrillation After Resection (AFAR): A PROGRESS III Study

Children

AZithromycin ThErapy for Chronic lung disease 2 (AZTEC2)

Long term follow-up of Azithromycin Therapy for Chronic Lung Disease of Prematurity

Brain Imaging in Babies (BIBS)

Brain Imaging and Infant Development Study

MARBLE Magnetic Resonance in Neonatal Encephalopathy

Magnetic Resonance Biomarkers in Neonatal Encephalopathy

Neonatal Antimicrobial Resistance and Outcomes (neoAMRO)

Neonatal Antimicrobial Resistance and Outcome (neoAMRO)

SurfON

Multicentre open label, pragmatic randomised controlled trial of early surfactant therapy versus expectant management in late preterm and early term infants with respiratory distress.

Erythropoietin and Darbepoetin in Neonatal Encephalopathy (EDEN) Trial

Erythropoietin and Darbepoetin in Neonatal Encephalopathy (EDEN) study

iGBS3

Development of a serocorrelate of protection against invasive Group B Streptococcus disease (iGBS)

The ELSA Study

The ELSA Study: EarLy Surveillance for Autoimmune diabetes

DOLFIN

Developmental Outcomes of Long Term Feed Supplementation in Neonates

WHEAT

WithHolding Enteral Feeds Around Blood Transfusion (WHEAT International Trial)

SLURP

Serial Lung Ultrasound in Predicted the need for surfactant and Respiratory course in Preterm infants – Observational Study

PRemature Infant Outcome Risk study

Prospective observational study on premature infant outcome risk

Critical Care

GenOMICC

Genetics of susceptibility and mortality in critical care (GenOMICC)

MARCH

Mucoatives in Acute Respiratory failure: Carbocisteine and Hypertonic saline

Statins for Improving Organ Outcome in Transplantation (SIGNET)

Statins in Organ Donor Management. An evaluation of the benefits of a single dose of Simvastin given to potential organ donors declared dead by neurological criteria on outcomes in organ recipients.

UK-ROX

Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care.

MOSAICC

Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Injury and metabolic acidosis.

Dementias

Currently no open (recruiting) studies at Medway NHS Foundation Trust. Go to https://bepartofresearch.nihr.ac.uk/ to find other sites.

Diabetes

DRN 552 (Incident and high risk type 1 diabetes cohort – ADDRESS-2)

An incident and high risk type 1 diabetes research cohort – After Diagnosis Diabetes REsearch Support System – 2 (ADDRESS-2)

Fetal Medicine

COPE

The Carboprost or Oxytocin Postpartum haemorrhage Effectiveness Study. Carboprost vs Oxytocin as the First Line Treatment of Primary Postpartum Haemorrhage; A phase IV, double-blind, double-dummy, randomised controlled trial.

Routine testing for Group B Streptoccocus

The clinical and cost-effectiveness of testing for Group B Streptoccus: a cluster randomised trial with economic and acceptability evaluations (GBS3)

First-trimester cfDNA Testing 

Clinical Implementation of Cell Free DNA Testing in Maternal Blood in the First-trimester of Pregnancy.

UKOSS: Pandemic Influenza in Pregnancy

Maternal and Perinatal Outcomes of Pandemic Influenza in Pregnancy

ASPRE-T

Aspirin versus placebo in twin pregnancies for preeclampsia prevention: A multicenter, randomised, double-blind, placebo-controlled trial (ASPRE-T)

Fetal Lung MRI (NANO)

The use of Advanced MRI techniques to evaluate antenatal lung development (NANO: MRI aNd Antenatal luNg develOpment)

Preeclampsia prevention by timing of birth: a randomised trial

Preeclampsia prevention by timing of birth: a randomised trial

Patient information sheet – U-LOOP study – Version 1.2- 25th July 2023

Prevention of PE PIS Version 1.2 Date 29.03.23 (Localised)

Evaluating the effectiveness of the Saving Babies Lives Care Bundle Version 2

Evaluating the effectiveness of the Saving Babies Lives Care Bundle Version 2 on reducing perinatal mortality (eVOLVE)

 

 

Injuries and Emergencies

Collar or no collar for peg fracture

DENS Trial: Duration of External Neck Stabilisation following odontoid fracture in older or frail adults: a randomised controlled trial of collar versus no collar

Musculoskeletal

IMID BioResource

IMID (Immune-Mediated Inflammatory Diseases) BioResource – part of MIHR BioResource

Toxicity from biologic therapy (BSRBR)

Prospective observational study of the long term hazards of biologic therapy in rheumatoid arthritis

Neurodegenerative Diseases

Currently no open (recruiting) studies at Medway NHS Foundation Trust. Go to Be Part of Research to find studies at other sites.

Neurology

MIDI (MR Imaging abnormality Deep learning Identification)

Deep Learning for Identification of Abnormalities on Head MRI

Respiratory (Lung)

REDUCE-Carbon

RandomisED control trial to Understand whether prescribing Choice for inhalErs is influenced by knowledge of the CARBON footprint

Rheumatology

Currently no open (recruiting) studies at Medway NHS Foundation Trust. Go to https://bepartofresearch.nihr.ac.uk to find other studies at other sites.

Surgery

CRAFFT- Children’s Radius Acute Fracture Fixation Trial

A multi-centre prospective randomised non-inferiority trial of surgical reduction versus non-surgical casting for displaced distal radius fractures in children.

Surgery or Cast for Injuries of the EpicoNdyle in Children’s Elbows

SCIENCE Surgery or Cast for Injuries of the EpicoNdyle in Children’s Elbows: A multi-centre prospective randomised superiority trial of operative fixation versus non-operative treatment for medial epicondyle fractures of the humerus in children.

SAPPHIRE

Safe Antimicrobial ProPhylaxis for surgery study

Ear, Nose & Throat

Currently no open (recruiting) studies at Medway NHS Foundation Trust. Go to Be Part of Research to find studies at other sites